This invention provides a multi-stage amplifier incorporating DC offset cancellation. The amplifier has a plurality of series-connected gain stages each of which comprises a differential amplifier unit generating a pair of differential outputs from a pair of differential inputs. In particular, a trailing stage in the plurality of gain stages comprises a digital DC offset cancellation module configured to compensate for a DC offset of the trailing stage's differential amplifier unit. The digital DC offset cancellation module comprises a comparator coupled to the pair of differential outputs of the trailing stage's differential amplifier unit for receiving such differential outputs as inputs for the comparator. Preferably, the comparator has an inherent DC offset that is substantially small. It is preferable that a non-trailing stage of the amplifier comprises an analog DC offset cancellation module for compensating for a DC offset of the non-trailing stage.