An analog disconnection envelope detection circuit having a low power supply detects a high speed, high differential voltage disconnect state on a data line. Level-shifting circuitry shifts the voltage level of two input signals by the value of a detection threshold voltage, generates differential signals used to indicate conditions of the input signals, and mitigates effects of input differential signal common-mode voltage on the detection operation. Circuitry is provided to equalize VDS of detecting tail current sources, thereby eliminating errors resulting from VDS mismatch of tail current sources. Comparator circuitry compares the sets of differential signals and indicates when the absolute difference between the two input signals is greater than a reference voltage. Output circuitry generates a disconnect signal corresponding to the disconnect condition. When compared to conventional disconnect detection circuitry, the disclosed circuit utilizes a relatively low supply voltage to detect high differential voltage disconnect conditions with improved accuracy.