Invention Grant
- Patent Title: Tripodal bisphosphonate derivatives
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Application No.: US13821321Application Date: 2011-09-07
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Publication No.: US08829233B2Publication Date: 2014-09-09
- Inventor: Wolfgang Maison , Elisa Franzmann , Faiza Khalil
- Applicant: Wolfgang Maison , Elisa Franzmann , Faiza Khalil
- Applicant Address: DE Giessen
- Assignee: Justus-Liebig-Universitaet Giessen
- Current Assignee: Justus-Liebig-Universitaet Giessen
- Current Assignee Address: DE Giessen
- Agency: Marshall, Gerstein & Borun LLP
- Priority: EP10176296 20100910
- International Application: PCT/EP2011/065495 WO 20110907
- International Announcement: WO2012/032093 WO 20120315
- Main IPC: C07F9/22
- IPC: C07F9/22 ; C07F9/38

Abstract:
The present invention describes tripodal bisphosphonate derivatives with a flexible basic framework for the functionalization of surfaces, and methods for their production and use. The central atom of the flexible framework is hereby a tertiary aliphatic carbon atom. A fourth remaining position of the flexible framework is suitable to be optionally functionalized by so-called click reactions, for example with biomolecules, polyethylene glycol or active agents.The compounds according to the present invention have the general formula X—C{(CH2)n—Y—C[PO(OH)2]2R1}3, wherein X stands for a group —(CH2)p—R3, wherein p=0 to 10 and R3 is selected from —H, —NH2, —NO2, —OH, —SH, —O—NH2, —NH—NH2, —N═C═S—, —N═C═O—, —CH═CH2, —C≡CH, —COOH, —(C═O)H, —(C═O)R4Y stands for —CH2—, —CH═CH—, —C≡C—, —O—, —S—, —S—S—, —NH—, —O—NH—, —NH—O—, —HC═N—O—, —O—N═CH—, —NR2—, -aryl-, -heteroaryl-, —(C═O)—, —O—(C═O)—, —(C═O)—O—, —NH—(C═O)—, —(C═O)—NH—, —NR2—(C═O)—, —(C═O)—NR2—, —NH—(C═O)—NH—, —NH—(C═S)—NH—, R1 represents a hydrogen atom or a hydroxy group, R2 stands for a linear or branched alkyl group and R4 for a linear or branched alkyl group or an aryl group. The production of the compounds occurs by reacting a compound X—C[(CH2)n—Y′]3 with a reagent Y″C[PO(OH)2]2R1 to the corresponding compound X—C{(CH2)n—Y—C[PO(OH)2]2R1}3 and subsequent purification of the reaction product. Y′ and Y″ are hereby precursors of Y. The compounds according to formula (I) according to the present invention are suitable to be used in a method to functionalize surfaces. The X group of the compounds according to the present invention is suitable to be optionally coupled to an effector, for example, by means of click chemistry.
Public/Granted literature
- US20130267731A1 Tripodal Bisphosphonate Derivatives Public/Granted day:2013-10-10
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