Invention Grant
US08828985B2 Carbamate and urea inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
有权
11-β-羟基类固醇脱氢酶的氨基甲酸酯和尿素抑制剂1
- Patent Title: Carbamate and urea inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
- Patent Title (中): 11-β-羟基类固醇脱氢酶的氨基甲酸酯和尿素抑制剂1
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Application No.: US13769256Application Date: 2013-02-15
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Publication No.: US08828985B2Publication Date: 2014-09-09
- Inventor: David A. Claremon , Suresh B. Singh , Colin M. Tice , Yuanjie Ye , Linghang Zhuang
- Applicant: David A. Claremon , Suresh B. Singh , Colin M. Tice , Yuanjie Ye , Linghang Zhuang
- Applicant Address: US PA Fort Washington
- Assignee: Vitae Pharmaceuticals, Inc.
- Current Assignee: Vitae Pharmaceuticals, Inc.
- Current Assignee Address: US PA Fort Washington
- Agency: McCarter & English LLP
- Agent Steven G. Davis; Michael J. DeGrazia
- Main IPC: A61K31/397
- IPC: A61K31/397 ; C07C15/20 ; C07D205/00
Abstract:
This invention relates to novel compounds of the Formula (I) pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds of the Formula (I) and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.
Public/Granted literature
- US20130244994A1 CARBAMATE AND UREA INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 Public/Granted day:2013-09-19
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