Invention Grant
US08828718B2 Gene transfer vectors comprising genetic insulator elements and methods to identify genetic insulator elements
有权
包含遗传绝缘子元件的基因转移载体和识别遗传绝缘子元件的方法
- Patent Title: Gene transfer vectors comprising genetic insulator elements and methods to identify genetic insulator elements
- Patent Title (中): 包含遗传绝缘子元件的基因转移载体和识别遗传绝缘子元件的方法
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Application No.: US13262696Application Date: 2010-04-02
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Publication No.: US08828718B2Publication Date: 2014-09-09
- Inventor: Odile Cohen-Haguenauer , Christian Auclair
- Applicant: Odile Cohen-Haguenauer , Christian Auclair
- Applicant Address: FR Paris
- Assignee: Centre National de la Recherche Scientifique
- Current Assignee: Centre National de la Recherche Scientifique
- Current Assignee Address: FR Paris
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- International Application: PCT/IB2010/000950 WO 20100402
- International Announcement: WO2010/113037 WO 20101007
- Main IPC: C12N15/00
- IPC: C12N15/00 ; C12N5/071
Abstract:
The present invention relates to a gene transfer vector (GTV) and in particular to an integrating gene transfer vector (IGTV), which comprises at least one genetic insulator element (GIE), wherein the each comprises at least two copies of an element selected from the group consisting of: a CTF binding site; a first CTCF binding site and a second CTCF binding site, wherein the first and the second CTCF binding sites are derived from the regulatory sequences of different genes.
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