Invention Grant
- Patent Title: Polynucleotides encoding therapeutic inhibitors of PAI-1
- Patent Title (中): 编码PAI-1治疗抑制剂的多核苷酸
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Application No.: US13769144Application Date: 2013-02-15
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Publication No.: US08828686B2Publication Date: 2014-09-09
- Inventor: Thomas D. Reed , Richard E. Peterson , Charles E. Reed , Joan Mazzarelli Sopczynski , Bethany L. Merenick , Jonathan Carson , Catherine L. Keaty , Elena Tasheva
- Applicant: Intrexon Corporation
- Applicant Address: US VA Blacksburg
- Assignee: Intrexon Corporation
- Current Assignee: Intrexon Corporation
- Current Assignee Address: US VA Blacksburg
- Agency: Sterne, Kessler, Goldstein & Fox P.L.L.C.
- Main IPC: C12N15/63
- IPC: C12N15/63 ; C12N1/20 ; C07K14/00 ; C07K14/81 ; C07K14/75 ; C07K14/78 ; C12N9/72 ; C12N9/44
Abstract:
The invention relates to mammalian PAI-I ligands and modulators. In particular, the invention relates to polypeptides, polypeptide compositions and polynucleotides that encode polypeptides that are ligands and/or modulators of PAI-I. The invention also relates to polyligands that are homopolyligands or heteropolyligands that modulate PAI-I activity. The invention also relates to ligands and polyligands localized to a region of a cell. The invention also relates to localization tethers and promoter sequences that can be used to provide spatial control of the PAI-I ligands and polyligands. The invention also relates to inducible gene switches that can be used to provide temporal control of the PAI-I ligands and polyligands. The invention also relates to methods of treating or preventing atherosclerosis. The invention also relates to methods of treating or preventing fibrosis.
Public/Granted literature
- US20130267022A1 Therapeutic Inhibitors of PAI-1 Function Methods of Their Use Public/Granted day:2013-10-10
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