Invention Grant
- Patent Title: Methods for the therapy of inflammatory bowel disease using a type-1 interferon antagonist
- Patent Title (中): 使用1型干扰素拮抗剂治疗炎症性肠病的方法
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Application No.: US13050601Application Date: 2011-03-17
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Publication No.: US08828393B2Publication Date: 2014-09-09
- Inventor: Lesley B. Pickford , Christopher R. Bebbington , Geoffrey T. Yarranton , David King
- Applicant: Lesley B. Pickford , Christopher R. Bebbington , Geoffrey T. Yarranton , David King
- Applicant Address: US NJ Princeton
- Assignee: Medarex, L.L.C.
- Current Assignee: Medarex, L.L.C.
- Current Assignee Address: US NJ Princeton
- Agency: Baker Botts L.L.P.
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/28 ; A61K39/00
Abstract:
Compositions and methods for the therapy of Inflammatory Bowel Disease (IBD), including Celiac Disease, Crohn's Disease, and Ulcerative Colitis, are disclosed. Illustrative compositions comprise one or more anti-type 1 interferon antagonists, such as anti-type 1 interferon receptor antibody antagonists and fragments thereof, as well as polypeptides and small molecules that inhibit the interaction of type 1 interferon with its receptor (IFNAR).
Public/Granted literature
- US20110165158A1 METHODS FOR THE THERAPY OF INFLAMMATORY BOWEL DISEASE USING A TYPE-1 INTERFERON ANTAGONIST Public/Granted day:2011-07-07
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