The technique introduced here involves using a block address and a corresponding generation number as a “fingerprint” to uniquely identify a sequence of data within a given storage domain. Each block address has an associated generation number which indicates the number of times that data at that block address has been modified. This technique can be employed, for example, to determine whether a given storage server already has the data, and to avoid sending the data to that storage server over a network if it already has the data. It can also be employed to maintain cache coherency among multiple storage nodes.