A personalized video generation system, including: (i) a digital asset manager for storing a video project file marked with references to content groups and content substitution rules; (ii) an editing tool for accessing the file and displaying content of the file grouped based on the groups, and generating an interface for substituting content across a video corresponding to the file, the interface adjusting the references for the digital asset manager; and (iii) a content generation engine for processing the file and the rules, based on personal data for intended recipients, to access content items and generating a plurality of video project files for rendering as corresponding videos for the recipients. The system can also include (iv) a distribution engine for communicating with a least one distribution gateway for a delivery platform; and (v) a least one render engine for receiving the video project files, causing rendering of the videos for a respective delivery platform, and forwarding the videos to the distribution engine for distribution of the videos for the respective delivery platform.