An adaptive slope-compensation method is applied for a switch-mode power supply. The switch-mode power supply has a power switch, and an inductor coupled to an input power. The power switch controls the inductor storing energy or releasing energy to generate an output voltage. The adaptive slope-compensation method includes detecting an inductor current passing through the inductor and to generate an inductor-current detecting voltage, detecting a duty cycle of the power switch, detecting a voltage variation of the inductor-current detecting voltage when the power switch is turned on, generating a slope-compensation signal according to the voltage variation and the duty cycle, and adjusting the timing of turning the power switch on or off. In this way, even if the operation conditions of the input power and the output voltage change, the system still can quickly response and does not generate sub-harmonic oscillation.