Invention Grant
US08796447B2 Process for producing benzo[B][1,4]diazepine-2,4-dione compound
有权
苯并[B] [1,4]二氮杂卓-2,4-二酮化合物的制备方法
- Patent Title: Process for producing benzo[B][1,4]diazepine-2,4-dione compound
- Patent Title (中): 苯并[B] [1,4]二氮杂卓-2,4-二酮化合物的制备方法
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Application No.: US13391468Application Date: 2010-08-20
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Publication No.: US08796447B2Publication Date: 2014-08-05
- Inventor: Hisayuki Tsujimori , Shinichi Taira , Hirotaka Yukawa , Kaoru Abe
- Applicant: Hisayuki Tsujimori , Shinichi Taira , Hirotaka Yukawa , Kaoru Abe
- Applicant Address: JP Tokyo
- Assignee: Otsuka Pharmaceutical Co., Ltd.
- Current Assignee: Otsuka Pharmaceutical Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Sughrue Mion, PLLC
- International Application: PCT/JP2010/064040 WO 20100820
- International Announcement: WO2011/021676 WO 20110224
- Main IPC: C07D243/12
- IPC: C07D243/12 ; C07D243/14
![Process for producing benzo[B][1,4]diazepine-2,4-dione compound](/abs-image/US/2014/08/05/US08796447B2/abs.jpg.150x150.jpg)
Abstract:
A process for producing a compound represented by formula (1), wherein each of R1, R2, R3 and R4, which may be the same or different, represents a hydrogen atom or a lower alkyl group, the process includes deprotecting a protective group (R5) of a compound represented by formula (2), wherein R1, R2, R3 and R4 are as defined above, and R5 represents a protective group of a hydroxy group. The process is an industrially advantageous, simple, and efficient process for producing a key intermediate of a benzo[b][1,4]diazepine-2,4-dione compound, which is a therapeutic medicine for arrhythmia.
Public/Granted literature
- US20120149899A1 PROCESS FOR PRODUCING BENZO[B][1,4]DIAZEPINE-2,4-DIONE COMPOUND Public/Granted day:2012-06-14
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