Invention Grant
US08796440B2 Promote system for regulatable gene expression in mammalian cells
有权
促进哺乳动物细胞中可调节基因表达的系统
- Patent Title: Promote system for regulatable gene expression in mammalian cells
- Patent Title (中): 促进哺乳动物细胞中可调节基因表达的系统
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Application No.: US13392954Application Date: 2010-08-20
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Publication No.: US08796440B2Publication Date: 2014-08-05
- Inventor: Feng Yao
- Applicant: Feng Yao
- Applicant Address: US MA Boston
- Assignee: The Brigham and Women's Hospital, Inc.
- Current Assignee: The Brigham and Women's Hospital, Inc.
- Current Assignee Address: US MA Boston
- Agency: Nixon Peabody LLP
- Agent David S. Resnick; Candace M. Summerford
- International Application: PCT/US2010/046252 WO 20100820
- International Announcement: WO2011/025717 WO 20110303
- Main IPC: C07K14/005
- IPC: C07K14/005 ; C12N7/00
Abstract:
The present invention is directed to a bidirectional human cytomegalovirus (hCMV) promoter that can be used to promote transcription on both strands of a double stranded DNA molecule. When used as part of a system that includes tet operator and the gene coding for the tet repressor, the promoter can be used to induce mammalian gene expression in a highly regulated way.
Public/Granted literature
- US20120190106A1 Promoter System for Regulatable Gene Expression in Mammalian Cells Public/Granted day:2012-07-26
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