Invention Grant
US08796002B2 Polypeptides for a ketoreductase-mediated stereoselective route to alpha chloroalcohols
有权
用于酮还原酶介导的对α-氯代醇的立体选择性途径的多肽
- Patent Title: Polypeptides for a ketoreductase-mediated stereoselective route to alpha chloroalcohols
- Patent Title (中): 用于酮还原酶介导的对α-氯代醇的立体选择性途径的多肽
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Application No.: US13378618Application Date: 2010-06-22
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Publication No.: US08796002B2Publication Date: 2014-08-05
- Inventor: Yong Koy Bong , Michael Vogel , Steven J. Collier , Vesna Mitchell , Jagadeesh Mavinahalli
- Applicant: Yong Koy Bong , Michael Vogel , Steven J. Collier , Vesna Mitchell , Jagadeesh Mavinahalli
- Applicant Address: US CA Redwood City
- Assignee: Codexis, Inc.
- Current Assignee: Codexis, Inc.
- Current Assignee Address: US CA Redwood City
- Agency: Codexis, Inc.
- International Application: PCT/US2010/039511 WO 20100622
- International Announcement: WO2011/005527 WO 20110113
- Main IPC: C12N9/04
- IPC: C12N9/04 ; C12P7/22 ; C12P17/02 ; C12N9/02 ; C12P21/00
Abstract:
The present disclosure relates to engineered ketoreductase polypeptides and uses thereof for the preparation of α chloroalcohols from α chloroketones. Also provided are polynucleotides encoding the engineered ketoreductase polypeptides and host cells capable of expressing the engineered ketoreductase polypeptides.
Public/Granted literature
- US20120190086A1 KETOREDUCTASE-MEDIATED STEREOSELECTIVE ROUTE TO ALPHA CHLOROALCOHOLS Public/Granted day:2012-07-26
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