Systems and methods of signal transmission and measuring for sensors employing a transmission medium are provided. In one embodiment, a method may comprise measuring a first monitored condition to generate a first monitored condition signal; converting the first monitored condition signal to a first frequency modulated signal having a first frequency; generating a second frequency modulated signal having a reference frequency; transmitting the first frequency modulated signal and the second frequency modulated signal using time division multiplexing; and wherein a first ratio of the first frequency and the reference frequency is associated with the first pressure.