Adaptive joint source channel coding associates multiple predictors with a reference data unit, such as a macroblock or frame of video data. An encoder determines a sub-codebook in which each of the selected multiple predictors decodes to the reference data unit. An identifier for the sub-codebook is transmitted through a channel to a decoder for subsequent decoding of the reference data unit. The reference data unit itself does not need to be sent. The multiple predictors are contained within a decoding region and the identifier for the sub-codebook specifies the decoding region. The decoder uses the identified sub-codebook and one of the predictors to decode the reference data unit. If none of the original predictors are correctly received, different types of error handling are employed based on the type of channel.