A variety of wireless communication methods and apparatus for supporting reconfiguration of radio link control (RLC) parameters are disclosed. A radio resource control (RRC) reconfiguration message is generated that indicates that an RLC unit in a wireless transmit/receive unit (WTRU) or a universal terrestrial radio access network (UTRAN) should be reconfigured from supporting flexible size RLC protocol data units (PDUs) to supporting fixed size RLC PDUs. If an information element (IE) “one sided RLC re-establishment” is present in the RRC reconfiguration message, only a receiving side subassembly in the RLC unit is re-established. Otherwise, both the receiving side subassembly and a transmitting side subassembly in the RLC unit are re-established. Flexible size RLC PDUs may be discarded and a message indicating the discarded flexible size RLC PDUs may be transmitted. The flexible size RLC PDUs may be modified such that they correspond to a set of pre-defined sizes.