Systems and methods for path selection for application commands are described. To this end, information associated with at least one application command that were processed at least one port of a target device is received. For a subsequent application command, a set of ports of the target device is determined. In one implementation, the set of ports is determined based on information associated with the subsequent application command. Once the set of ports is determined, the subsequent application command is directed to a port selected from the set of ports.