The present invention extends to methods, systems, and computer program products for targeted data transfer data between operational domains. Embodiments of the invention facilitate moving data between operational domains inside and outside of a resource cloud. A proxy runs on the boundary of each operational domain, such as, for example, an on premise cluster and a resource cloud. The proxies are capable of resolving the location of the targeted entity and forwarding the data or request on to the next hop, which may either be another proxy or the worker module running on the target node. A proxy can run on the head node of an on premise cluster so that compute nodes on private networks can be targeted. A proxy can also run on a public endpoint within the resource cloud to make nodes within the resource cloud available.