The invention relates to a method for channel estimation using a dedicated pilot signal in an OFDM-based communication system with multi-antenna transmission techniques. The receiver estimates the statistical characteristics of a virtual channel generated by beamforming by exploiting the statistical characteristics of common pilot channel, determines the optimum dedicated pilot pattern, and estimates the channel from dedicated pilot signal transmitted in an optimum pattern by means of AMMSE interpolation. The invention minimizes the channel estimation error by exploiting the statistical characteristics of the virtual channel, and optimally determines the dedicated pilot pattern according to the operation environment to maximize the transmission performance in terms of the pilot signaling overhead and the channel estimation error. In particular, the invention is very effective in low signal-to-interference plus noise power ratio (SINR) operation environments.