A flexible clock synthesizer technique includes generating a phase interpolator calibration signal to adjust a phase interpolator output signal generated by a phase interpolator of an interpolative divider. The phase interpolator is responsive to a phase interpolator control code and an output signal of a fractional-N divider of the interpolative divider. The phase interpolator calibration signal is based on an error signal indicative of a phase interpolator error. The error signal may indicate a phase relationship between a reference clock signal and a feedback clock signal of a PLL. The interpolative divider may be coupled in a feedback path of the PLL. The PLL may receive a reference clock signal and the feedback clock signal may be an adjusted phase interpolator output signal. The phase interpolator calibration signal may be a phase interpolator offset code corresponding to the phase interpolator control code or a phase interpolator gain signal.