Invention Grant
- Patent Title: Methods and compositions for reducing amyloid beta levels
- Patent Title (中): 降低淀粉样蛋白β水平的方法和组合物
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Application No.: US13847092Application Date: 2013-03-19
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Publication No.: US08691519B2Publication Date: 2014-04-08
- Inventor: Li Gan , Lennart Mucke
- Applicant: The J. David Gladstone Institutes
- Applicant Address: US CA San Francisco
- Assignee: The J. David Gladstone Institutes
- Current Assignee: The J. David Gladstone Institutes
- Current Assignee Address: US CA San Francisco
- Agency: Bozicevic, Field & Francis LLP.
- Agent Paula A. Borden
- Main IPC: C12Q1/37
- IPC: C12Q1/37 ; G01N33/53 ; C12N9/50
Abstract:
The present invention provides methods for reducing the level of amyloid beta protein in a cell or tissue, the methods generally involving contacting the cell or tissue with an agent that reduces cystatin C levels and/or activity. The present invention provides methods for treating Alzheimer's disease (AD), and methods for treating cerebral angiopathy, in an individual, the methods generally involving administering to an individual having AD a therapeutically effective amount of an agent that reduces cystatin C levels and/or activity. The present invention further provides methods for identifying an agent that reduces cystatin C levels and/or activity.
Public/Granted literature
- US20130273035A1 Methods and Compositions for Reducing Amyloid Beta Levels Public/Granted day:2013-10-17
Information query
