Invention Grant
US08691210B2 Methods and compositions for generating an immune response by inducing CD40 and pattern recognition receptors and adaptors thereof
有权
通过诱导CD40和模式识别受体及其适配器产生免疫应答的方法和组合物
- Patent Title: Methods and compositions for generating an immune response by inducing CD40 and pattern recognition receptors and adaptors thereof
- Patent Title (中): 通过诱导CD40和模式识别受体及其适配器产生免疫应答的方法和组合物
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Application No.: US12445939Application Date: 2007-10-19
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Publication No.: US08691210B2Publication Date: 2014-04-08
- Inventor: David M Spencer , Natalia Lapteva
- Applicant: David M Spencer , Natalia Lapteva
- Agency: Grant Anderson LLP
- International Application: PCT/US2007/081963 WO 20071019
- International Announcement: WO2008/049113 WO 20080424
- Main IPC: C12N15/85
- IPC: C12N15/85
Abstract:
Provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing pattern recognition receptor activity, and CD40 activity. Also provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing CD40 activity without prostaglandin E2. Also provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing an inducible chimeric molecule comprising a region of a pattern recognition receptor or an adaptor thereof.
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