Invention Grant
- Patent Title: Imaging agents for detecting neurological disorders
- Patent Title (中): 用于检测神经系统疾病的成像剂
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Application No.: US13035405Application Date: 2011-02-25
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Publication No.: US08691187B2Publication Date: 2014-04-08
- Inventor: Anna Katrin Szardenings , Wei Zhang , Dhanalakshmi Kasi , Anjana Sinha , Umesh B. Gangadharmath , Joseph C. Walsh
- Applicant: Anna Katrin Szardenings , Wei Zhang , Dhanalakshmi Kasi , Anjana Sinha , Umesh B. Gangadharmath , Joseph C. Walsh
- Applicant Address: US IN Indianapolis
- Assignee: Eli Lilly and Company
- Current Assignee: Eli Lilly and Company
- Current Assignee Address: US IN Indianapolis
- Agent Manisha A Desai; Zhigang Rao; Kyle W. Grimshaw
- Main IPC: A61K49/00
- IPC: A61K49/00

Abstract:
Imaging agents of formulas (I)-(V) and methods for detecting neurological disorders comprising administering to a patient in need compounds of formulas (I)-(V) capable of binding to tau proteins and β-amyloid peptides are presented herein. The invention also relates to methods of imaging Aβ and tau aggregates comprising introducing a detectable quantity of pharmaceutical formulation comprising a radiolabeled compound of formulas (I)-(V) and detecting the labeled compound associated with amyloid deposits and/or tau proteins in a patient. These methods and compositions enable preclinical diagnosis and monitoring progression of AD and other neurological disorders.
Public/Granted literature
- US20110182812A1 Imaging Agents for Detecting Neurological Disorders Public/Granted day:2011-07-28
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