Invention Grant
US08691165B2 Methods, reagents, devices and instrumentation for preparing impregnated tissue samples suitable for histopathological and molecular studies
有权
用于制备适合于组织病理学和分子研究的浸渍组织样品的方法,试剂,装置和仪器
- Patent Title: Methods, reagents, devices and instrumentation for preparing impregnated tissue samples suitable for histopathological and molecular studies
- Patent Title (中): 用于制备适合于组织病理学和分子研究的浸渍组织样品的方法,试剂,装置和仪器
-
Application No.: US11997285Application Date: 2006-07-31
-
Publication No.: US08691165B2Publication Date: 2014-04-08
- Inventor: Carla Duymelinck , Mark Kockx
- Applicant: Carla Duymelinck , Mark Kockx
- Applicant Address: BM Edegem
- Assignee: Histogenex N.V.
- Current Assignee: Histogenex N.V.
- Current Assignee Address: BM Edegem
- Agency: Knobbe, Martens, Olson & Bear LLP
- Priority: WOPCT/EP2005/008253 20050729
- International Application: PCT/EP2006/007576 WO 20060731
- International Announcement: WO2007/014741 WO 20070208
- Main IPC: A61B10/00
- IPC: A61B10/00

Abstract:
A process for the production of paraffin sections of biological tissue, especially for molecular pathology studies is disclosed. In the process, the tissue sample is simultaneously fixed, dehydrated and cleared in a first step, subsequently dehydrated and cleared in a second step and infiltrated with an inert specimen matrix in a third step. The specimen can then be further embedded in a casting supporting matrix according to the standard procedures followed by any local pathology or research laboratory. A kit and a processing station for automating paraffin embedding of a tissue sample suitable for histopathological and molecular analysis is also described. A bio-indicator system is described for measuring the degree of crosslinking. A tissue sample holding means or a vial which includes a tissue sample holding means provided with a data logging device capable of registering and transmitting data regarding the sample and conditions where the sample was processed is also disclosed.
Public/Granted literature
Information query