A soothing apparatus and an infant seat therewith are disclosed. The soothing apparatus includes an apparatus base, a seat base disposed on the apparatus, and a driving device including a driving part and a follower disposed on the apparatus base and the seat base oppositely. The driving part has an interfering surface with a specific profile. The follower keeps contacting the interfering surface such that the seat base is moved through the follower relative to the apparatus base in accordance with the specific profile when the interfering surface moves relative to the follower. Thereby, the soothing apparatus can provide an specific soothing motion and further provide another variant soothing motion by just creating another specific profile, so that the invention can provide a more flexible mechanism than that in the prior art.