A system and methods for adding a personal touch to auto-reply email messages is presented herein. The system and method involve a user enabling a personalized auto-reply feature in their email client, the email client communicating such enablement to a related email server, the email server receiving an email message for the user, the email server determining personal identifier of the sender of the email message and the email server sending a personalized auto-reply using the determined personal identifier to compose and send an auto-reply with a personal touch. The email server may determine the personal identifier through searching one of the user's address book or a global address list for an address entry having the reply address found in the received message's header or the email server may search the body of the received email message to determine personal identifier.