A method for improving clinical trial compliance for a business entity using a computer system including a database is provided. The method includes selecting a clinical trial facility and at least one clinical trial subject, creating a clinical trial protocol including at least medical service cost data for an insurance company and a clinical trial sponsor, establishing a second subsystem including a software application that schedules appointments, establishing a third subsystem including a software application that that generates invoices, storing the clinical trial protocol, the second subsystem and the third subsystem in the database. The method also includes providing communication means between the clinical trial protocol, the second subsystem and the third subsystem, performing a medical service on the at least one clinical trial subject and determining a corresponding medical service cost, and comparing the medical service cost against the clinical trial protocol to determine whether the medical service cost is included in the clinical trial protocol.