Systems and methods for operably coupling medical device(s) together with an evaluation device such that closed-loop processing may occur are provided. To achieve closed-loop processing, the evaluation device is configured to receive diagnostic information related to physiological attributes of a patient and operational-status information of the medical device(s). Upon receipt of this information, the evaluation device may automatically analyze the data and automatically compose instructions based on the analysis. Analyzing includes comparing the data against content within an electronic medical record (EMR) or applying rules to the data. The rules are built on evidence-based medical procedures consistent with current medical practice. The instructions, when distributed and implemented, invoke actions at the medical device(s), such as dispensing a medication and reprogramming configuration settings, as well as actions at a notification component configured to request a healthcare professional to intervene in a patient's treatment and to provide feedback of medical events.