Invention Grant
- Patent Title: Enzyme catalysts for diels-alder reactions
- Patent Title (中): 用于鳗鱼反应的酶催化剂
-
Application No.: US13130260Application Date: 2009-11-19
-
Publication No.: US08688427B2Publication Date: 2014-04-01
- Inventor: David Baker , Alexandre Zangellini , Justin Siegel , Jennifer St. Clair
- Applicant: David Baker , Alexandre Zangellini , Justin Siegel , Jennifer St. Clair
- Applicant Address: US WA Seattle
- Assignee: University of Washington
- Current Assignee: University of Washington
- Current Assignee Address: US WA Seattle
- Agency: Cooley LLP
- International Application: PCT/US2009/065127 WO 20091119
- International Announcement: WO2010/077470 WO 20100708
- Main IPC: G01N33/50
- IPC: G01N33/50 ; G01N33/48 ; C12N9/10
Abstract:
The present invention provides enzyme catalysts for Diels-Alder reactions, including intermolecular Diels-Alder reactions, as well as protein scaffolds for making such enzyme catalysts. In other aspects, the invention provides methods of making the enzyme catalysts, including by de novo computational design. The present invention thereby provides enzyme catalysts capable of catalyzing a desired Diels-Alder reaction, including with a specified or desired stereo-selectivity.
Public/Granted literature
- US20120100594A1 ENZYME CATALYSTS FOR DIELS-ALDER REACTIONS Public/Granted day:2012-04-26
Information query
IPC分类:
