Systems and methods are presented that detect and classify mass-like regions exhibiting spiculated and/or dense characteristics with high sensitivity and at acceptable false positive rates. One or more suspicious masses are identified in medical imagery of the breast. In certain embodiments, a quantitative measure of spiculation and quantitative measure of density are computed for each suspicious mass located. At least one classification scheme, developed using true and false positives with similar quantitative measures, is then selected for each suspicious mass according to both quantitative measures. In certain other embodiments, a measure of breast location is computed for each suspicious mass. In one embodiment, the location determines whether a suspicious mass appears inside or outside of the parenchyma region of the breast.