A method and device for transmitting semi-persistent scheduling (SPS) data reduces the probability of retransmitting a semi-persistent service, and increases the system throughput. The method includes: determining an initial transmission carrier for transmitting SPS data according to channel condition information of each carrier in multiple carriers and a gain of a match of a multi-user multiple-input and multiple-output (MU-MIMO) antenna unit; instructing, to a user, the determined initial transmission carrier for transmitting SPS data; and transmitting the SPS data to the user through the instructed initial transmission carrier for transmitting SPS data. The method and device are mainly applied to a process for transmitting SPS data in a carrier aggregation scenario.