In order to satisfy the conflicting requirements for spectrum sensing and QoS of data transmission, it is highly desirable for a cognitive radio system, e.g. IEEE 802.22 WRAN, to perform spectrum sensing and data transmission simultaneously. Embodiments of the invention address critical issues of self-interference generated from a transmission unit to the co-located sensing unit when the simultaneous sensing and data transmission technique is applied. A number of interference mitigation techniques are described and analysis are given.