A safety control structure for heater wire comprises a switch, a first heating wire, a second heating wire, and an over-current protection element, which are sequentially connected in series connection. An insulation and fusible layer is interposed between the first heating wire and the second heating wire. Accordingly, under normal condition, the switch is triggered by triggering the circuit, so as to have the first heating wire and the second heating wire then be heated up within a preset temperature range. When the first heating wire and the second heating wire produce exceptionally high temperatures to fuse the insulation and fusible layer, the current is increased instantaneously because the first heating wire and the second heating wire are short-circuited. Therefore, the circuit is interrupted by the over-current protection element to show a broken circuit status in order to stop heating up.