Invention Grant
US08685947B2 Compositions and methods for loop diuretics with consistent bioavailability
有权
具有一致生物利用度的循环利尿剂的组合物和方法
- Patent Title: Compositions and methods for loop diuretics with consistent bioavailability
- Patent Title (中): 具有一致生物利用度的循环利尿剂的组合物和方法
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Application No.: US13217764Application Date: 2011-08-25
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Publication No.: US08685947B2Publication Date: 2014-04-01
- Inventor: Edith Mathiowitz , Bryan Laulicht
- Applicant: Edith Mathiowitz , Bryan Laulicht
- Applicant Address: US RI Providence
- Assignee: Brown University
- Current Assignee: Brown University
- Current Assignee Address: US RI Providence
- Agency: Lawson & Weitzen, LLP
- Agent Sonia K. Guterman; Anna E. Stanford
- Main IPC: A01N51/00
- IPC: A01N51/00 ; A61K31/655 ; A61K47/32 ; B32B5/16 ; B32B9/00 ; B32B15/02 ; B32B17/02 ; B32B19/00 ; B32B21/02 ; B32B23/02 ; B32B27/02 ; C07D307/02
Abstract:
Diuretic bioactivity profiles of phase inversion micronized furosemide and furosemide co-precipitated with Eudragit L100, and mixtures of those formulations with stock furosemide, reduced or eliminated the rapid spike in diuresis associated with immediate release formulations and maintained cumulative urine output. Of the formulations tested, each of a mixture of micronized furosemide with stock furosemide, and Eudragit L100 polymer with stock furosemide demonstrated optimal diuretic bioactivity profiles in subjects.
Public/Granted literature
- US20120053156A1 COMPOSITIONS AND METHODS FOR LOOP DIURETICS WITH CONSISTENT BIOAVAILABILITY Public/Granted day:2012-03-01
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