Invention Grant
US08685660B2 Genetic alterations in isocitrate dehydrogenase and other genes in malignant glioma
有权
异柠檬酸脱氢酶和恶性胶质瘤中其他基因的遗传改变
- Patent Title: Genetic alterations in isocitrate dehydrogenase and other genes in malignant glioma
- Patent Title (中): 异柠檬酸脱氢酶和恶性胶质瘤中其他基因的遗传改变
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Application No.: US13060191Application Date: 2009-09-03
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Publication No.: US08685660B2Publication Date: 2014-04-01
- Inventor: Bert Vogelstein , Kenneth W. Kinzler , D. Williams Parsons , Xiaosong Zhang , Jimmy Cheng-Ho Lin , Rebecca J. Leary , Philipp Angenendt , Nickolas Papadopoulos , Victor Velculescu , Giovanni Parmigiani , Rachel Karchin , Sian Jones , Hai Yan , Darell Bigner , Chien-Tsun Kuan , Gregory J. Riggins
- Applicant: Bert Vogelstein , Kenneth W. Kinzler , D. Williams Parsons , Xiaosong Zhang , Jimmy Cheng-Ho Lin , Rebecca J. Leary , Philipp Angenendt , Nickolas Papadopoulos , Victor Velculescu , Giovanni Parmigiani , Rachel Karchin , Sian Jones , Hai Yan , Darell Bigner , Chien-Tsun Kuan , Gregory J. Riggins
- Applicant Address: US MD Baltimore US NC Durham
- Assignee: The Johns Hopkins University,Duke University
- Current Assignee: The Johns Hopkins University,Duke University
- Current Assignee Address: US MD Baltimore US NC Durham
- International Application: PCT/US2009/055803 WO 20090903
- International Announcement: WO2010/028099 WO 20100311
- Main IPC: G01N33/574
- IPC: G01N33/574
Abstract:
We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in glioblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas.
Public/Granted literature
- US20110229479A1 GENETIC ALTERATIONS IN ISOCITRATE DEHYDROGENASE AND OTHER GENES IN MALIGNANT GLIOMA Public/Granted day:2011-09-22
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