Invention Grant
- Patent Title: Misuse preventative, controlled release formulation
- Patent Title (中): 滥用预防性,控释制剂
-
Application No.: US13919499Application Date: 2013-06-17
-
Publication No.: US08685447B2Publication Date: 2014-04-01
- Inventor: Miloud Rahmouni , Sonia Gervais , Vinayak Sant , Damon Smith , Frederic Duffayet , Shams Rustom , Ali El-Jammal , Jean-Michel Ndong , Ali Bichara
- Applicant: Paladin Labs Inc. , Paladin Labs (Barbados) Inc. , Paladin Labs Europe Limited
- Applicant Address: CA Montreal (Quebec) BB Hastings, Christ Church IE Dublin
- Assignee: Paladin Labs Inc.,Paladin Labs (Barbados) Inc.,Paladin Labs Europe Limited
- Current Assignee: Paladin Labs Inc.,Paladin Labs (Barbados) Inc.,Paladin Labs Europe Limited
- Current Assignee Address: CA Montreal (Quebec) BB Hastings, Christ Church IE Dublin
- Agency: Goodwin Procter LLP
- Main IPC: A61K9/20
- IPC: A61K9/20

Abstract:
Disclosed is a misuse preventative, controlled release composition in the form of a multilayered oral dosage form. A first layer contains a plurality of controlled release microparticles having a pharmaceutically active agent (for example, an opioid analgesic) disposed therein. A second layer comprises a pharmaceutically active agent that can be the same or different from the pharmaceutically active agent in the microparticles. The composition further comprises a superabsorbent material disposed within the first layer, the second layer, or both the first layer and the second layer. When crushed, either intentionally or accidentally, and exposed to an aqueous medium, the superabsorbent material swells to encapsulate the microparticles, which remain substantially intact thereby retarding the release of the pharmaceutically active agent from the composition.
Public/Granted literature
- US20140004191A1 MISUSE PREVENTATIVE, CONTROLLED RELEASE FORMULATION Public/Granted day:2014-01-02
Information query