Invention Grant
US08685413B2 Heterologous protection against Pasteurella multocida provided by P. multocida fur cells and the outer-membrane protein extracts thereof
失效
对多巴梭菌毛皮细胞提供的多杀巴斯德氏菌的异源保护及其外膜蛋白质提取物
- Patent Title: Heterologous protection against Pasteurella multocida provided by P. multocida fur cells and the outer-membrane protein extracts thereof
- Patent Title (中): 对多巴梭菌毛皮细胞提供的多杀巴斯德氏菌的异源保护及其外膜蛋白质提取物
-
Application No.: US12865287Application Date: 2009-01-29
-
Publication No.: US08685413B2Publication Date: 2014-04-01
- Inventor: Jorge Barbe Garcia , Ignacio Badiola Saiz , Montserrat Llagostera Casas , Maria Elena Garrido Ocana , Montserrat Bosch Gallego , Ana Maria Perez De Rozas Ruiz De Gauna
- Applicant: Jorge Barbe Garcia , Ignacio Badiola Saiz , Montserrat Llagostera Casas , Maria Elena Garrido Ocana , Montserrat Bosch Gallego , Ana Maria Perez De Rozas Ruiz De Gauna
- Applicant Address: ES Barcelona
- Assignee: Universitat Autonoma de Barcelona
- Current Assignee: Universitat Autonoma de Barcelona
- Current Assignee Address: ES Barcelona
- Agency: Sughrue Mion, PLLC
- Priority: ES200800239 20080130
- International Application: PCT/ES2009/000046 WO 20090129
- International Announcement: WO2009/095518 WO 20090806
- Main IPC: A61K39/02
- IPC: A61K39/02 ; A61K39/00 ; A61K39/38 ; A61K39/102 ; C12N1/20 ; C07K1/00 ; C07K14/00 ; C07K17/00
Abstract:
The invention relates to Pasteurella multocida mutants capable of providing heterologous protection against infection caused by virulent P. multocida . Said mutants are defective in fur ompH and fur ompH galE genes. The invention relates to Pasteurella multocida bacteria vaccine compositions containing fur ompH double mutants and fur ompH galE triple mutants obtained from P. multocida , or an extract of iron-regulated outer-membrane proteins (IROMPs) obtained from said mutants, and to an excipient and/or pharmaceutically acceptable adjuvants.
Public/Granted literature
Information query
