Invention Grant
- Patent Title: Insulin-like growth factor signaling and integrin
- Patent Title (中): 胰岛素样生长因子信号转导和整合素
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Application No.: US13146907Application Date: 2010-01-29
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Publication No.: US08685403B2Publication Date: 2014-04-01
- Inventor: Yoshikazu Takada , Jun Saegusa
- Applicant: Yoshikazu Takada , Jun Saegusa
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Kilpatrick Townsend & Stockton LLP
- International Application: PCT/US2010/022561 WO 20100129
- International Announcement: WO2010/088502 WO 20100805
- Main IPC: A61K39/00
- IPC: A61K39/00 ; C07K14/00
Abstract:
Interaction between insulin-like growth factor 1 (IGFI) and integrin is involved in integrin-mediated cellular signaling, such as enhanced proliferation of cells expressing integrins, especially integrin alpha v beta 3, alpha 6 beta. 1 and alpha 6. beta. 4. A method for inhibiting integrin signaling by using an inhibitor of IGFI-integrin binding is disclosed A method for identifying inhibitors of IGFI-integrin binding is also described. Further disclosed are polypeptides, nucleic acids, and corresponding compositions for inhibiting integrin signaling.
Public/Granted literature
- US20120082675A1 INSULIN-LIKE GROWTH FACTOR SIGNALING AND INTEGRIN Public/Granted day:2012-04-05
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