A continuous process for making a multi-panel sterilization assembly, the process including the steps of: providing a moving, continuous base web; providing a plurality of subassemblies; applying the subassemblies in position on the moving, continuous base web to define repeating portions that incorporate the subassemblies and alternating portions that lack such subassemblies; providing side tabs; applying the side tabs in position on the moving, continuous base web with respect to at least one edge of the portions that incorporate the subassemblies; attaching the subassemblies and the side tabs to the moving, continuous base web to form a continuous work-piece; and separating the continuous work-piece into individual multi-panel sterilization assemblies, each multi-panel sterilization assembly comprising a barrier panel, a fold protection panel and at least one side tab.