Example methods, apparatus, and articles of manufacture to determine pliable air duct configurations are disclosed. A disclosed example method involves determining a first quantity of adjustable air outlet duct sections to configure an air delivery duct system when an operating mode identifier is received. The operating mode identifier is associated with an amount of air delivered by the air delivery duct system into targeted areas. The first quantity of adjustable air outlet duct sections is based on an airflow rate value and the operating mode identifier. The airflow rate value is indicative of airflow through an air delivery duct system. Each adjustable air outlet duct section includes at least one adjustable air outlet having at least one size-adjustable orifice.