A numerical control machine tool has two spindles mounted in opposition to each other. In order to enable consecutive operations of lathe turning machining work in accordance with a speed command, drill machining work for drilling with rotating tools with a work positioned at a given angle, and other machining works while keeping a state where a single work is grasped by both of the spindles, switching means 152, 215 and 225 are provided which switch a reference spindle 314 to a profile control axis in a state where both of the spindles are held in the position control mode selected during spindle synchronized control, in a case where a C-axis control switching command is issued to treat the reference spindle 314 as the profile control axis while spindle synchronized control is performed for the reference spindle 314 and a synchronized spindle 324 and the synchronized spindle 324 is revolving at a command speed given to the reference spindle 314.