Data storage and retrieval methods and apparatus are provided for facilitating data de-duplication for serial-access storage media such as tape. During data storage, input data is divided into a succession of chunks and, for each chunk, a corresponding data item is written to the storage media. The data item comprises the chunk data itself where it is the first occurrence of that data, and otherwise comprises a chunk-data identifier identifying that chunk of subject data. To facilitate reconstruction of the original data on read-back from the storage media a cache (50) is used together with a database (35R), stored on the media, that includes for each duplicated chunk, the location of the corresponding chunk of subject data.