Computer-implemented systems, methods, and computer-readable media for reducing operational costs relating to fuel burn of aircraft include receiving trip data specifying an origin, an intermediate destination, and a final destination from a client device; receiving operational data from one or more computing device; performing optimization logic to determine an optimized route having a minimized fuel cost, the optimized route specifying how much fuel to purchase at each of an origin airport, an intermediate destination airport, and a final destination airport; and transmitting the optimized route to the client device.