A method and system for improving picture quality of color images by combing the content of a plurality of frames of the same subject; comprising: at least one processor; the at least one processor comprising a memory for storing a plurality of frames of a subject; the at least one processor operating to combine the content of plurality of frames of the subject into a combined color image by performing: a process in which at least two multicolored frames are converted to monochromatic predetermined color frames; a gross shift process in which the gross shift translation of one monochromatic predetermined color frame is determined relative to a reference monochromatic predetermined color frame; a subpixel shift process utilizing a correlation method to determine the translational and/or rotational differences of one monochromatic predetermined color frame to the reference monochromatic predetermined color frame to estimate sub-pixel shifts and/or rotations between the frames; and an error reduction process to determine whether the resolution of the resulting combined color image is of sufficient resolution; the error reduction process comprising applying at least one spatial frequency domain constraint and at least one spatial domain constraint to the combined color image to produce at least one high-resolution full color image.