Invention Grant
- Patent Title: Process for the preparation of (poly) aminoalkylaminoacetamide derivatives of epipodophyllotoxin useful for their applications in therapeutics as anticancer agent
- Patent Title (中): 用于制备用于治疗作为抗癌剂的表鬼臼毒素的（多）氨基烷基氨基乙酰胺衍生物的方法
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Application No.: US12733864Application Date: 2008-09-23
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Publication No.: US08664409B2Publication Date: 2014-03-04
- Inventor: Yves Guminski , Martial Grousseaud , Thierry Imbert
- Applicant: Yves Guminski , Martial Grousseaud , Thierry Imbert
- Applicant Address: FR Boulogne Billancourt
- Assignee: Pierre Fabre Medicament
- Current Assignee: Pierre Fabre Medicament
- Current Assignee Address: FR Boulogne Billancourt
- Agency: Hueschen and Sage
- Priority: FR0706693 20070925
- International Application: PCT/FR2008/051700 WO 20080923
- International Announcement: WO2009/050365 WO 20090423
- Main IPC: C07D307/77
- IPC: C07D307/77
Abstract:
The present invention relates to a new process for the preparation of (poly)aminoalkylaminoacetamide derivatives of epipodophyllotoxin and salts thereof, characterized in that it comprises a step of peptide coupling of 4-amino-4′-demethylepipodophyllotoxin with an amine-containing reactant having protecting groups.
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