Invention Grant
- Patent Title: Method for producing 3-halo-1,2-benzisothiazoles
- Patent Title (中): 3-卤代-1,2-苯并异噻唑的制备方法
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Application No.: US13634450Application Date: 2011-03-14
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Publication No.: US08664404B2Publication Date: 2014-03-04
- Inventor: Shigeki Sakaue , Sachio Iida
- Applicant: Shigeki Sakaue , Sachio Iida
- Applicant Address: JP Kako-gun
- Assignee: Sumitomo Seika Chemicals Co., Ltd.
- Current Assignee: Sumitomo Seika Chemicals Co., Ltd.
- Current Assignee Address: JP Kako-gun
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2010-086377 20100402
- International Application: PCT/JP2011/055943 WO 20110314
- International Announcement: WO2011/125423 WO 20111013
- Main IPC: C07D275/04
- IPC: C07D275/04

Abstract:
A method for producing a 3-halo-1,2-benzisothiazole represented by the general formula (2): wherein R1 is a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, an alkoxycarbonyl group having 2 to 5 carbon atoms, a nitro group or a halogen atom, and X is a halogen atom, the method characterized by reacting a 1,2-benzisothiazol-3-one represented by the general formula (1): wherein R1 is the same group as the R1 defined in the above general formula (2), with a thionyl halide in a polar solvent. The 3-halo-1,2-benzisothiazole obtainable according to the method of the present invention is suitably used as production raw materials and the like for a medicament and the like.
Public/Granted literature
- US20130005983A1 METHOD FOR PRODUCING 3-HALO-1,2-BENZISOTHIAZOLES Public/Granted day:2013-01-03
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