Invention Grant
- Patent Title: Compounds and methods for PKCθ inhibition
- Patent Title (中): PKCθ抑制的化合物和方法
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Application No.: US13861646Application Date: 2013-04-12
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Publication No.: US08664277B2Publication Date: 2014-03-04
- Inventor: Janet Ajioka , Heidi S. Hummel , Rich B. Meyer , John Swindle
- Applicant: Complegen Partners, LLC
- Applicant Address: US WA Seattle
- Assignee: CompleGen Partners, LLC
- Current Assignee: CompleGen Partners, LLC
- Current Assignee Address: US WA Seattle
- Agency: Kilpatrick Townsend & Stockton LLP
- Main IPC: C07C217/90
- IPC: C07C217/90 ; C07C323/37
Abstract:
The present invention provides a method of selectively inhibiting PKCθ in the presence of PKCδ, by administering to a subject in need thereof, a therapeutically effective amount of a compound of Formula I. The present invention also provides a method of inhibiting cytokine synthesis in a T cell, a method of inhibiting T cell proliferation, and a method of inhibiting the replication of and cytokine production by T lymphocytes, while not stimulating or inhibiting the replication of B lymphocytes.
Public/Granted literature
- US20130225687A1 COMPOUNDS AND METHODS FOR PKC THETA INHIBITION Public/Granted day:2013-08-29
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