Invention Grant
- Patent Title: Dual-acting imidazole antihypertensive agents
- Patent Title (中): 双效咪唑降压药
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Application No.: US13685148Application Date: 2012-11-26
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Publication No.: US08664254B2Publication Date: 2014-03-04
- Inventor: Seok-Ki Choi , Paul R. Fatheree , Robert Murray McKinnell , Brooke Olson
- Applicant: Seok-Ki Choi , Paul R. Fatheree , Robert Murray McKinnell , Brooke Olson
- Applicant Address: US CA South San Francisco
- Assignee: Theravance, Inc.
- Current Assignee: Theravance, Inc.
- Current Assignee Address: US CA South San Francisco
- Agent Jeffrey A. Hagenah; Shelley Eberle
- Main IPC: A61K31/4164
- IPC: A61K31/4164 ; C07D233/54
Abstract:
The invention is directed to compounds having the formula: wherein: Ar, r, R2-3, X, and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
Public/Granted literature
- US20130245087A1 DUAL-ACTING IMIDAZOLE ANTIHYPERTENSIVE AGENTS Public/Granted day:2013-09-19
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