Invention Grant
US08664234B2 Dihydrobenzoquinazolinone M1 receptor positive allosteric modulators
有权
二氢苯并喹唑啉酮M1受体阳性变构调节剂
- Patent Title: Dihydrobenzoquinazolinone M1 receptor positive allosteric modulators
- Patent Title (中): 二氢苯并喹唑啉酮M1受体阳性变构调节剂
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Application No.: US13825137Application Date: 2011-09-29
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Publication No.: US08664234B2Publication Date: 2014-03-04
- Inventor: Scott D. Kuduk , Ronald K. Chang , Thomas J. Greshock
- Applicant: Scott D. Kuduk , Ronald K. Chang , Thomas J. Greshock
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Sylvia A. Ayler; John C. Todaro
- International Application: PCT/US2011/053813 WO 20110929
- International Announcement: WO2012/047702 WO 20120412
- Main IPC: A01N43/54
- IPC: A01N43/54 ; C07D239/70
Abstract:
The present invention is directed to dihydrobenzoquinazilinone compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.
Public/Granted literature
- US20130184298A1 DIHYDROBENZOQUINAZOLINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS Public/Granted day:2013-07-18
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