Invention Grant
US08664233B2 Substituted 5H-pyrimido[5,4-B]indoles, method for the production thereof and use thereof for treating non-solid malignant tumors of the blood-producing system
失效
取代的5H-嘧啶并[5,4-B]吲哚，其制备方法及其用于治疗产血系统的非固体恶性肿瘤
![Substituted 5H-pyrimido[5,4-B]indoles, method for the production thereof and use thereof for treating non-solid malignant tumors of the blood-producing system](/docs/US/2014-03-04/US08664233B2/abs.jpg.600x600.jpg)
- Patent Title: Substituted 5H-pyrimido[5,4-B]indoles, method for the production thereof and use thereof for treating non-solid malignant tumors of the blood-producing system
- Patent Title (中): 取代的5H-嘧啶并[5,4-B]吲哚，其制备方法及其用于治疗产血系统的非固体恶性肿瘤
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Application No.: US12520480Application Date: 2007-12-21
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Publication No.: US08664233B2Publication Date: 2014-03-04
- Inventor: Claudia Reichelt , Alexander Schulze , Mohammed Daghish , Friedrich-Alexander Ludwig , Jochen Heinicke , Konrad Herrmann , Maj Schuster , Sven Letschert , Kenneth Mugridge , Joseph DeAngelo
- Applicant: Claudia Reichelt , Alexander Schulze , Mohammed Daghish , Friedrich-Alexander Ludwig , Jochen Heinicke , Konrad Herrmann , Maj Schuster , Sven Letschert , Kenneth Mugridge , Joseph DeAngelo
- Applicant Address: DE Leipzig
- Assignee: The Medicines Company (Leipzig) GmbH
- Current Assignee: The Medicines Company (Leipzig) GmbH
- Current Assignee Address: DE Leipzig
- Agency: Hultquist PLLC
- Agent Steven J. Hultquist; Mary B. Grant
- Priority: DE102006062203 20061222
- International Application: PCT/EP2007/011387 WO 20071221
- International Announcement: WO2008/077631 WO 20080703
- Main IPC: A01N43/54
- IPC: A01N43/54 ; A61K31/505 ; A01N43/38 ; A61K31/40
![Substituted 5H-pyrimido[5,4-B]indoles, method for the production thereof and use thereof for treating non-solid malignant tumors of the blood-producing system](/abs-image/US/2014/03/04/US08664233B2/abs.jpg.150x150.jpg)
Abstract:
The invention relates to compounds of general formula 1 to processes for the production thereof, to pharmaceutical preparations containing said compounds and/or physiologically compatible salts and/or solvates which can be produced therefrom as well as to the pharmaceutical use of said compounds, the salts or solvates thereof as inductors of apoptosis in the case of non-solid malignant tumors of the hematopoietic system, in particular in the case of leukemias and lymphomas, more particularly in the case of leukemic B lymphocytes.
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